PURPOSE: A base, a nucleoside, or a nucleotide effectively is provided to suppress virus replication with less side effects and to be used as an antiviral pharmaceutical composition. CONSTITUTION: An antiviral pharmaceutical composition contains one or more selected from the group consisting of adenine, guanine, uracil, cytosine, adenosine, guanosine, uridine, cytidine, adenosine biphosphate, and adenosine triphosphate. Rhinovirus is selected among rhinovirus type 2, 3, 14, 15, and 40. Enterovirus is enterovirus type 71. A pharmaceutical composition for anti-influenza virus contains adenosine and/or adenine as active ingredients. The influenza virus is influenza virus type A.본 발명은 부작용이 적고, 많은 아형을 가지는 라이노바이러스, 엔테로바이러스 또는 인플루엔자 바이러스와 같은 바이러스에 대하여, 효과적인 바이러스 증식 억제활성을 가지는 염기, 뉴클레오사이드, 또는 뉴클레오타이드에 관한 것이다.