作為凝血因子ＸＩＡ抑制劑之具有雜環Ｐ２’基團之巨環化合物农业专利-农业专业知识服务系统

发明人:: CORTE, JAMES R.,柯德　詹姆士Ｒ,DELUCCA, INDAWATI,德鲁卡　印达瓦提,德魯卡　印達瓦提,FANG, TIANAN,方天安,YANG, WU,杨　武,楊　武,WANG, YUFENG,王裕丰,王裕豐,DILGER, ANDREW K.,戴尔杰　安德鲁Ｋ,戴爾傑　安德魯Ｋ,PABBISETTY, KUMAR BALASHANMUGA,帕比斯提　库,柯德詹姆士R,德鲁卡印达瓦提,德魯卡印達瓦提,杨武,楊武,戴尔杰安德鲁K,戴爾傑安德魯K,帕比斯提库

摘要：: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.本發明提供式(I)化合物：或其立體異構物、互變異構物或醫藥上可接受之鹽，其中所有變量皆如本文中所定義。該等化合物係選擇性凝血因子XIa抑制劑或FXIa及血漿激肽釋放素之雙重抑制劑。本發明亦係關於包含該等化合物之醫藥組合物及使用其治療血栓栓塞性及/或發炎性病症之方法。