Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication using such Compounds and methods for treating viral infections involving the administration of such Compounds The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.本發明描述選擇性抑制病理性產生人類血管內皮生長因子(VEGF)之化合物及包含該等化合物之組合物。本發明描述抑制病毒複製之化合物及包含該等化合物之組合物。亦描述使用該等化合物減少VEGF之方法及包含投與該等化合物來治療癌症及非腫瘤病症之方法。另外描述使用該等化合物抑制病毒複製之方法及包含投與該等化合物來治療病毒感染之方法。該等化合物可呈單劑療法形式或與一或多種其他療法組合投與需要該等治療之人類。