<;P>;PROBLEM TO BE SOLVED: To provide a method for producing a soluble ephippium having especially high adhesive and proliferation effects of a fibroblast. <;P>;SOLUTION: The method for producing the soluble ephippium includes subjecting ephippium to hydrolysis, and bringing the obtained hydrolysis product into contact with an anion exchange resin. <;P>;COPYRIGHT: (C)2009,JPO&INPIT