Kenneth L. Roland;Kevin P. Killeen;Lawrence J. Thomas
发明人:
Kevin P. Killeen,Kenneth L. Roland,Lawrence J. Thomas
申请号：
US13573963
公开号：
US20130122039A1
申请日:
2012.10.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the hyperexpression of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
