KILLEEN, KEVIN P.,ROLAND, KENNETH L.,THOMAS, LAWRENCE J.
申请号：
CA2684742
公开号：
CA2684742C
申请日:
2008.04.24
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant cholera toxin B antigen by attenuated, live bacterial vectors derived from Vibrio cholerae are disclosed. The compositions exhibit dual immunogenicity and retain the ability to colonize gastrointestinal mucosa-associated lymphoid tissues.
