Disclosed is a medical module connection base (20,30), comprising a support wall (22,31) for supporting a medical module (10), a side wall (23,32) arranged on the support wall (22,31), and a signal transmission assembly which is arranged on the support wall (22,31) or the side wall (23,32) and communicates signals with the medical module (10). Further disclosed is a medical module expansion system, comprising a first medical module connection base (30) and a second medical module connection base (20) which are connected to and combined with a medical module (10), so that the medical module (10) can be functionally expanded and exchange data with external equipment conveniently.