PROBLEM TO BE SOLVED: To provide a therapeutic agent containing a compound (GIRK channel activation current suppressing compound) having a suppressing action on an activated current of a G-protein coupled inwardly-rectifying K+ (GIRK) channel, or optionally, other therapeutic agents for schizophrenia such as clozapine, as an active ingredient.SOLUTION: The therapeutic agent for schizophrenia contains the compound (GIRK channel activation current suppressing compound) having a suppressing action on an activated current of GIRK channel such as tipepidine as an active ingredient. The agent is effective on a positive symptom and/or negative symptom of schizophrenia, and also has few side effects.COPYRIGHT: (C)2013,JPO&INPIT【課題】G-タンパク質共役型内向き整流性K+(GIRK)チャンネルの活性化電流を抑制する作用を有する化合物(GIRKチャンネル活性化電流抑制化合物)または必要に応じクロザペン等の他の統合失調症治療薬を有効成分として含有する統合失調症治療薬を提供すること。【解決手段】この発明に係る統合失調症治療薬は、チぺピジンなどのGIRKチャンネル活性化電流抑制作用を有する化合物(GIRKチャンネル活性化電流抑制化合物)を、有効成分として含有する、統合失調症の陽性症状および/または陰性症状にも有効で、かつ、副作用が少ない薬剤である。【選択図】なし
