PROBLEM TO BE SOLVED: To provide a drug for improving a central function which contains a compound (GIRK channel inhibiting compound) having an inhibiting action on a GIRK channel activated current, as an active ingredient.SOLUTION: The drug for improving the central function contains the compound (GIRK channel inhibiting compound) having the inhibiting action on the GIRK channel activated current, as the active ingredient, is effective to an obsessional model wherein an existing drug, namely an SSRI such as fluvoxamine is not effective, and has few side effects.COPYRIGHT: (C)2012,JPO&INPIT【課題】GIRKチャネル活性化電流抑制作用を有する化合物(GIRKチャネル抑制化合物)を、有効成分として含有する中枢機能改善薬を提供すること。【解決手段】この発明に係る中枢機能改善薬は、GIRKチャネル活性化電流抑制作用を有する化合物(GIRKチャネル抑制化合物)を、有効成分として含有し、かつ、特に既存薬、つまりフルボキサミンなどのSSRIでは効果がなかった強迫性モデルに対して有効であるとともに、副作用が少ない薬剤である。【選択図】なし
