HILPERT, Kurt,HUBLER, Francis,KIMMERLIN, Thierry,MURPHY, Mark,RENNEBERG, Dorte,STAMM, Simon
申请号：
ES12756563
公开号：
ES2574840T3
申请日:
2012.07.20
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), ** Formula ** in which n represents 1 or 2； one of X and Y represents -N- or -N (O) - and the other represents -N- or -C (R6) -； R1 represents hydrogen or methyl and R2 represents hydrogen, (C1-C2) alkyl, deuteroalkyl (C1-C2), hydroxy-methyl or heterocyclyl-methyl； or R1 and R2 form, together with the carbon atom to which they are attached, a saturated carbocyclic ring of 3 to 6 members； and R3 represents an aryl, an aryloxy, an aryl (C1-C2) alkyl, a heteroaryl or a heteroaryloxy group, groups which are independently mono-, di-, tri-, or tetra-substituted aromatic moieties, in which the substituents are independently selected from the group consisting of (C1-C3) alkyl, cycloalkyl (C3-C6), alkoxy (C1-C3), hydroxy (C1-C2) alkyl, fluoroalkyl (C1-C3), fluoroalkoxy (C1 -C3), (C1-C2) alkylcarbonyl, cyano, -CONH2, halogen and phenoxy； or R1 represents hydrogen and R2 and R3 form, together with the carbon atom to which they are attached, an indanyl group or a tetrahydronaphthyl group, groups that are independently mono-, di-, tri-, or tetra-substituted aromatic moiety , wherein the substituents are independently selected from the group consisting of (C1-C3) alkyl, fluoroalkyl (C1-C3) and halogen； and R4, R5 and R6 independently represent each other hydrogen, (C1-C3) alkyl, (C3-C6) cycloalkyl, (C1-C3) alkoxy, (C1-C3) fluoroalkyl or halogen； or a pharmaceutically acceptable salt of such compound.Un compuesto de fórmula (I),**Fórmula** en la que n representa 1 o 2； uno de X e Y representa -N- o -N(O)- y el otro representa -N- o -C(R6)-； R1 representa hidrógeno o metilo y R2 representa hidrógeno, alquilo (C1-C2), deuteroalquilo (C1-C2), hidroxi-metilo o heterociclil-metilo； o R1 y R2 forman, junto con el átomo de carbono al cual están unidos, un anillo carbocíclico saturado de 3 a 6 miembros； y R3 representa un arilo, un ariloxi, un arilalquilo (C1-C2), un heteroarilo o un grupo heteroariloxi, grupos que están en el resto aromático independientemente
