Benzofuranos, benzotiofenos, benzoselenofenos e indoles sustituidos y su uso como inhibidores de la polimerización de tubulina

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专利权人:

BIONOMICS LIMITED

发明人:

CHAPLIN, JASON,GILL, GURMIT,GROBELNY, DAMIAN,FLYNN, BERNARD,KREMMIDIOTIS, GABRIEL

申请号：

ES07701434

公开号：

ES2386299T3

申请日:

2007.02.02

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

A compound of formula (I) or a salt thereof ** Formula ** in which: X represents O, S, SO, SO2, Se, SeO, SeO 2 or NR where R is selected from H, O, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkyl, optionally substituted aryl , cicloalqueniloopcionalmente, optionally substituted cycloalkyl, optionally substituted heteroaryl, heterocicliloopcionalmente substituted and sulfonyl optionally substituted R1a and R1b each independently represent H, carboxy, cyano, dihalometoxi, halogen, hydroxy, nitro, pentahaloethyl, phosphorylamino, phosphono, phosphinyl, sulfo, trihaloetenilo trihalomethoxy trihalometanotio, trihalomethyl, aciloopcionalmente substituted acylamino, optionally substituted acylimino, optionally substituted aciliminoxiopcionalmente substituted acyloxy, optionally substituted arylalkyl, optionally substituted arilalcoxiopcionalmente substituted, optionally substituted alkenyl, optionally substituted alkenyloxy, alcoxiopcionalmente their I tituido, optionally substituted alkyl, optionally substituted alkynyl, alquiniloxiopcionalmente substituted, optionally substituted amino, aminoacyl, optionally substituted aminoaciloxiopcionalmente substituted aminosulfonyl optionally substituted aminotioacilo optionally substituted ariloopcionalmente substituted aryloxy, optionally substituted, optionally substituted cycloalkenyl, cicloalquiloopcionalmente, optionally substituted heteroaryl, optionally substituted heterocyclyl, oxiaciloopcionalmente substituted, oxyacylamino optionally substituted oxiaciloxi optionally substituted oxiaciliminoopcionalmente substituted oxisulfinilamino optionally substituted oxisulfonilamino optionally substituted oxitioacilo optionally substituted, optionally substituted oxitioaciloxi, sulfinyl, optionally substituted sulfinylamino optionally substituted, optionally substituted sulfonyl, sulfonylamino optionally substituted, tioopcionalm being substituted, optionally substituted acylthio, optionall

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