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Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles And Their Use as Tubulin Polymerisation Inhibitors
专利权人:
发明人:
申请号:
EP12153534.8
公开号:
EP2460793A1
申请日:
2007.02.02
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.whereinX represents O, S, SO, SO2, Se, SeO, SeO2 or NR where R is selected from H, O, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, and optionally substituted sulfonylR1C represents C1-3 alkoxy, C1-3 alkylthio, C1-3 alkylamino, or C1-3 dialkylaminoR1D represents hydroxy or aminoL represents C=O, O, S, SO, SO2, Se, SeO, SeO2, C=NZ, or NR where Z is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted amino and where R is selected from H, O, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or optionally substituted sulfonylThe other variables are as defined in the claims.
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