雙特異性抗體农业专利-农业专业知识服务系统

发明人:: BENNETT, ERIC M.,贝内特　埃瑞克Ｍ,貝內特　埃瑞克Ｍ,GIMENO, RUTH E.,吉米诺　茹丝Ｅ,吉米諾　茹絲Ｅ,HIGGINSON-SCOTT, NATHAN,希金森　史考特　奈森,MARQUETTE, KIMBERLY A.,玛奎德　金伯利Ａ,瑪奎德　金伯利Ａ,PAULSEN, JANET E.,保尔森　珍妮特Ｅ,保爾森　珍妮特Ｅ,TCHISTIAKO,贝内特埃瑞克M,貝內特埃瑞克M,吉米诺茹丝E,吉米諾茹絲E,希金森史考特奈森,玛奎德金伯利A,瑪奎德金伯利A,保尔森珍妮特E,保爾森珍妮特E

摘要：: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.本發明係關於經工程改造之雜多聚體蛋白質，且更特定地關於用於產生及純化諸如雙特異性抗體之雜二聚體蛋白質之方法。亦提供用於產生及純化此經工程改造之雜二聚體蛋白質的方法及該雜二聚體蛋白質在診斷學及治療學中之用途。本發明亦關於一種特異性結合人類TrkB之人類化抗體，及用於產生該抗體及使用該抗體以特別治療聽覺喪失病症之方法。