The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.本發明係關於TrkB結合激動劑以及此等激動劑於治療神經病症和其他病症之用途。本發明亦關於包括CDR、可變區、重鏈和輕鏈以及其變體序列之特異性TrkB結合激動劑。