Claim 1: A compound of the formula (1) and isomers, stereoisomers, atropisomers, conformers, tautomers, polymorphs, hydrates and solvates thereof； where, Y⁻ is anion of Y； Y is selected from nitric acid, C₂₋₁₂ alkyl sulfonic acid, C₃₋₁₂ cycloalkyl sulfonic acid, primary bile acids, secondary bile acids, conjugated bile acids, CH₃- (CH₂) ᶻ-COOH, C₄₋₁₄ alkane branched carboxylic acid, C₄₋₁₄ alkene carboxylic acid, C₄₋₁₄ alkyne carboxylic acid and C₃₋₁₂ cycloalkane carboxylic acid； z is selected from 1 to 14； n is selected from 0 to 5；Lessor；acyl, acyloxy, C₁₋₈ alkoxycarbonyl, sulfonamido, halo, cyano and nitro； R² is selected from R⁴,-C (O) R-C (O) NHR-SO₂R⁴,-C (o) No. 8309； r8310 or formula structure (2)；A,-NHR8308；acyloxy and sulfonamide； R⁴ is selected from C₁₋₈ alkyl, C₁₋₈ perhaloalkyl, C₃₋₈ cycloalkyl, hetero-C₃₋₁₄ cycloalkyl, aryl, aryl-C₁₋₈ alkyl and heteroaryl； R⁵ and R⁶ are independently selected from hydrogen, C₁₋₈ alkyl, C₃₋₈ cycloalkyl, aryl, aryl-C₁₋₈ alkyl and heteroaryl or R⁵ and R⁶ together may form a saturated or unsaturated 4-8 membered monocyclic or bicyclic ring , may be fused with benzene, which may optionally contain one to two heteroatoms, selected from O, N and S.Reivindicación 1: Un compuesto de la fórmula (1) e isómeros, estereoisómeros, atropisómeros, confórmeros, tautómeros, polimorfos, hidratos y solvatos de los mismos； en donde, Y⁻ es anión de Y； Y se selecciona de ácido nítrico, C₂₋₁₂ alquil ácido sulfónico, C₃₋₁₂ cicloalquil ácido sulfónico, ácidos biliares primarios, ácidos biliares secundarios, ácidos biliares conjugados, CH₃-(CH₂)ᶻ-COOH, C₄₋₁₄ alcano ácido carboxílico ramificado, C₄₋₁₄ alqueno ácido carboxílico, C₄₋₁₄ alquino ácido carboxílico y C₃₋₁₂ cicloalcano ácido carboxílico； z se selecciona de 1 a 14； n se selecciona de 0 a 5； R¹ se selecciona independientemente de hidrógeno, C₁₋₈ alquilo, C₁₋₈ perhaloalquilo, C₃₋₈ cicloalquilo, hetero-C₃₋₁₄ cicloalquilo, arilo, aril-C₁₋₈ alquilo, heteroarilo, heteroaril-C₁₋₈ alquilo, C₁₋₈ alc
