The present invention relates to novel polypeptides having a skin whitening activity and use thereof. More particularly, the present invention relates to an isolated polypeptide consisting (essentially) of any one amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, and SEQ ID NO: 7, a skin whitening cosmetic composition comprising the polypeptide as an active ingredient, or a pharmaceutical composition for preventing or treating a pigmentation disease.
