Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor

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专利权人:

发明人:

申请号：

EP12189613.8

公开号：

EP2573112A1

申请日:

2008.10.10

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The invention relates to modulating the SIRPα - CD47 interaction in order to increase hematopoietic stem cell engraftment and compounds therefor. In some embodiments, there is provided isolated SIRPα and CD47 polypeptides, fragments and fusion proteins for enhancing hematopoietic stem cell engraftment. Further there is provided methods for increasing hematopoietic stem cell engraftment through administration of the above polypeptides.

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