Prasolava, Tatiana,Dick, John E.,Takenaka, Katsuto,Danska, Jayne
申请号:
AU2008310263
公开号:
AU2008310263B2
申请日:
2008.10.10
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The invention relates to modulating the SIRPα - CD47 interaction in orderto increase hematopoietic stem cell engraftment and compounds therefor. Insome embodiments, there is provided isolated SIRPα and CD47 polypeptides,fragments and fusion proteins for enhancing hematopoietic stem cell engraftment.Further there is provided methods for increasing hematopoietic stem cell engraftmentthrough administration of the above polypeptides.