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ENDOGLYCOSIDASE ISSUE DE STREPTOCOCCUS PYOGENES ET SES PROCEDES D'UTILISATION
专利权人:
GENOVIS AB
发明人:
COLLIN, MATTIAS,ALLHORN, MARIA,SJOGREN, JONATHAN
申请号:
CA2848230
公开号:
CA2848230C
申请日:
2012.09.12
申请国别(地区):
CA
年份:
2020
代理人:
摘要:
The invention provides an endoglycosidase, referred to as EndoS49 and having the amino acid sequence of SEQ ID NO: 1. EndoS49 was isolated from Streptococcus pyogenes strain NZ131 and is a homologue of EndoS. EndoS49 has specific endoglycosidase activity on native IgG and cleaves a larger variety of Fc glycans than EndoS. A mutant thereof where the glutamic acid at position 186 of SEQ ID NO: 1 was substituted was produced: said mutant lacks endoalvcosidase activity but is capable of binding to IgG. Methods using EndoS49, deletions thereof and said mutant, especially for assessing glycosylation of IgG or for isolating IgG are disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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