The present invention relates to a (poly)peptide having Epidermal Growth Factor (EGF)-activity or a nucleic acid encoding said (poly)peptide for use in treating or preventing a demyelinating and/or neurodegenerating disorder, wherein the (poly)peptide (a) comprises or consists of the amino acid sequence of SEQ ID NO: 1； and/or (b) comprises or consists of an amino acid sequence, which is at least 66% identical to the amino acid sequence of SEQ ID NO: 1； and/or (c) comprises or consists of a fragment of (a) or (b)； and wherein the (poly)peptide or nucleic acid is the only pharmaceutically active agent to be administered.
