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IMMUNOMODULATION METHODS
专利权人:
ПОЛИМЕДИКС, ИНК. (US);ЮНИВЕРСИТИ ОФ МЕДСИН ЭНД ДЕНТИСТРИ ОФ НЬЮ ДЖЕРСИ (US);ПОЛИМЕДИКС; ИНК. (US)
发明人:
СКОТТ Ричард В. (US),ДАЙМОНД Джилл (US)
申请号:
RU2013105255/15
公开号:
RU2013105255A
申请日:
2011.07.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of correcting an immune response in a mammal, comprising administering to the mammal a therapeutically effective amount of a compound: a) Formula I: or a pharmaceutically acceptable salt thereof, in which: X is O or S; R is straight or branched chain C 1-6 alkyl, if necessary substituted with one or more —NH or —NH — C (NH NH) NH; Y is a bond or carbonyl; Z is a bond or carbonyl; R is hydrogen or straight or branched C — Calkyl, optionally substituted with one or more —NH or —NH -C (= NH) NH; or R is t-XR; R is methylene, or wherein methylene is substituted with straight or branched chain C 1-6 alkyl, wherein straight or branched chain C 1-6 alkyl may be substituted with one or more -NH or -NH-C (= NH) NH; n = 2 -10; and m = 1 or 2; b) Formula II: or a pharmaceutically acceptable salt thereof, in which: X is O or S; Y is O or S; R is H or -C (= O) -A, where A is straight or branched C -Calkyl, optionally substituted with one or more -NH, -N (CH) or -NH-C (= NH) NH; R is straight or branched C-Calkyl, optionally substituted with one or more -NH, -N ( CH) or —NH — C (═NH) NH; R is straight or branched C — C alkyl, optionally substituted with one or more —NH, —N (CH) or —NH — C (= NH) NH; and R is H, -B or -C (= O) -OB, where B is straight or branched C-C1-6 alkyl; c) Formulas III: or a pharmaceutically acceptable salt thereof, in which: each A independently is —C = O, - C = S or CH; each D independently is O or S; each R is independently hydrogen, C1-6alkyl, alkoxy, halogen or halogenated; each R is independently hydrogen, C1-6alkyl, alkoxy, halogen or haloalkyl; each R is independently denotes water1. Способ коррекции иммунного ответа у млекопитающего, включающий введение млекопитающему терапевтически эффективного количества соединения:a) Формулы I:или его фармацевтически приемлемой соли,в которой:X обозначает O или S;Rобозначает C-Cалкил с прямой или разветвленной цепью, в случае необходимости замещенный одним или более -NHили -NH-C(=NH)NH;Y обозначает с
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