Institute of Pharmacology and Toxicology Academy of Military Medical Sciences;Biomedical Analysis Center Academy of Military Medical Sciences
发明人:
申请号：
EP17741124.6
公开号：
EP3398934A4
申请日:
2017.02.22
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Disclosed area hydroquinone compound, a preparation method therefor, and use thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compound is as shown by formula I, wherein X is C=O or CH 2 ； Y is NH, O or absent； R is selected from any one of the following groups: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms； and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compound provided by the present invention can slowly releases 2-tert-butyl-4-methoxyphenol in vivo, overcomes the disadvantage that the half-life of 2-tert-butyl-4-methoxyphenol directly adminisitered in the body is short (T1/2 = 0.5ˆ¼1h), and maintains stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T1/2=12ˆ¼24h). The compound provided by the present invention protects the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoids the oxidation in the environment and increases the enviromental stability of drugs.
