Carl H. June,Michael Milone,Yangbing Zhao,Lawrence G. Lum,Archana Thakur
申请号：
US15756244
公开号：
US20180282693A1
申请日:
2016.08.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an intracellular signaling molecule in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.
