The Trustees of the University of Pennsylvania;Wayne State University
发明人:
Carl H. June,Michael Milone,Yangbing Zhao,Lawrence G. Lum,Archana Thakur
申请号：
US15754227
公开号：
US20180243341A1
申请日:
2016.08.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and bispecific antibodies in T cells, the T cells are metabolically enhanced with improved cytotoxicity and resistance to immunosuppression imposed by tumor microenvironments. Certain aspects include modified T cells and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with enhanced immunity.
