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ЦЕФДИНИРА КИСЛАЯ СОЛЬ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ
专利权人:
ZHEJIANG ADAMERCK BIOPHARMLABS INC.
发明人:
QI YOUMAO,Кви Юмао,YE FENGQI,Е Фенжи,JIE QING,Джи Цин,QI YINGBEI,Кви Инбей,ZHANG FENGMIN,Чжан Фенмин,YU BAOCHUN,Ю Баочан,YE TIANJIAN,Е Тянцзян,YU MEIPING,Ю Мейпин
申请号:
RU2011133302/04
公开号:
RU0002531276C2
申请日:
2009.12.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a cefdinir acid salt, represented by formula I, where M represents Na+, K+, NH4+, or Cs+ Y represents SO4 2- or PO4 3-, and 1) if Y represents SO4 2-: if m=1, then n=1 if m=0.5, then n=1.5 and 2) if Y represents PO4 3-: if m=1, then n=2. Also claimed is a method of obtaining the cefdinir acid salt of formula (I), including preparation of a homogeneous mixture of cefdinir with a solvent, drop introduction into the homogenous mixture of cefdinir of a solution with an equimolar quantity of acid from the group: sulphuric acid, phosphoric acid, with further addition to the obtained transparent solution of an ammonium compound from the group: ammonium acetate, ammonium propionate, gaseous ammonia, aqueous ammonia solution, or with further addition to the obtained transparent solution of a compound of alkali metal from the group: sodium, potassium, cesium or into the homogenous cefdinir mixture introduced by drop introduction is an equimolar amount of ammonium hydrosulphate or hydrosulphate of alkali metal from the group: sodium, potassium, or ammonium dihydrophosphate or alkali dihydrophosphate of alkali metal from the group: sodium, potassium, after which the obtained product of reaction, taking place for 15 minutes, is concentrated, crystallised, filtered and dried. In case, if acid or the compound contains a sulphate group, the obtained product is cefdinir acid salt, and if acid or the compound contains a phosphate group, the obtained product is cefdinir phosphate salt.EFFECT: cefdinir acid salt, possessing high solubility.8 cl, 2 tbl, 48 exИзобретение относится к цефдинира кислой соли, представленной формулой I, где M представляет собой Na+, K+, NH4+, или Cs+ Y представляет собой или , при этом 1) если Y представляет : если m=1, то n=1 если m=0.5, то n=1.5 и 2) если Y представляет : если m=1, то n=2. Также предложен способ получения цефдинира кислой соли формулы (I), предусматривающий подготовку гомогенной смеси цефдин
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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