The subject of the invention covers the substituted derivatives of dicarboximides represented by the general formula 1: possibly in the form of pharmaceutically acceptable salts, wherein R means the alkyl group C1-C6, optionally, the alkyl group is substituted with -OH group or amine group, selected from group containing -NH-R 1 group or the group with formula 2 or 3, where R 1 , R 2 , R 3 are the same or different and cover the alkyl group C1-C3 and R 4 means -CH 2 - or -O- and the application of these compounds, or in combination with other drugs.