DUMONT, Guy,ANSERMINO, Mark,KHOSRAVI, Sara,WEST, Nicholas
申请号：
EP16867484
公开号：
EP3380133A4
申请日:
2016.11.23
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage； a monitor for measuring an effect of the drug on the patient； and a controller configured to determine a control signal to the drug administration actuator； wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement； wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient； and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
