PROCEDES D'ADMINISTRATION ET D'EVALUATION DE MEDICAMENTS A RECUPERATION D'AZOTE POUR LE TRAITEMENT DE L'ENCEPHALOPATHIE HEPATIQUE

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专利权人:

HYPERION THERAPEUTICS; INC.

发明人:

SCHARSCHMIDT, BRUCE,MOKHTARANI, MASOUD

申请号：

CA2891657

公开号：

CA2891657A1

申请日:

2013.11.21

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present disclosure provides methods for treating hepatic encephalopathy (HE) and for optimizing and adjusting nitrogen scavenging drug dosage for subjects with HE, comprising administering a nitrogen scavenging drug at a dosage sufficient to maintain a. fasting blood ammonia level at or below a specified threshold level which is 1.5 times the upper limit of normal for blood ammonia. The nitrogen scavenging drug administered in the method is a phenylacetic acid prodrug selected from HPN-100, PBA, NaPBA, sodium benzoate, or any combination thereof (i.e., any combination of two or more of HPN-100, PBA, NaPBA).

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