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PROCEDES D'ADMINISTRATION ET D'EVALUATION DE MEDICAMENTS A RECUPERATION D'AZOTE POUR LE TRAITEMENT DE L'ENCEPHALOPATHIE HEPATIQUE
专利权人:
HYPERION THERAPEUTICS; INC.
发明人:
SCHARSCHMIDT, BRUCE,MOKHTARANI, MASOUD
申请号:
CA2891657
公开号:
CA2891657A1
申请日:
2013.11.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present disclosure provides methods for treating hepatic encephalopathy (HE) and for optimizing and adjusting nitrogen scavenging drug dosage for subjects with HE, comprising administering a nitrogen scavenging drug at a dosage sufficient to maintain a. fasting blood ammonia level at or below a specified threshold level which is 1.5 times the upper limit of normal for blood ammonia. The nitrogen scavenging drug administered in the method is a phenylacetic acid prodrug selected from HPN-100, PBA, NaPBA, sodium benzoate, or any combination thereof (i.e., any combination of two or more of HPN-100, PBA, NaPBA).
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