ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA;UNIVERSITY OF HAWAII
发明人:
Robert A. Nichols,Kelly Forest,Victor J. Hruby
申请号：
US16326777
公开号：
US20190233487A1
申请日:
2017.08.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Peptide analogues of β-amyloid and methods of using said analogues for neuroprotection are described herein. The β-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal β-amyloid core fragment. A pharmaceutical composition of the β-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The β-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against β-amyloid toxicity.
