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PLATINUM NANOCOMPOUNDS AND METHODS OF APPLYING THEREOF
专利权人:
DZE BRIGKHEHM EHND VIMENZ KHOSPITEHL; INK.;DZE BRIGKHEHM EHND VIMEN'Z KHOSPITEHL
发明人:
SENGUPTA Shiladit'ja (US),СЕНГУПТА Шиладитья (US),PARASKAR Abkhiman'ju (US),ПАРАСКАР Абхиманью (US),SONI Shivani (US),СОНИ Шивани (US),SENGUPTA Poulomi (US),СЕНГУПТА Поуломи (US),BASU Sudipta (US),БАС,SENGUPTA SHILADITJA,СЕНГУПТА Шиладитья,PARASKAR ABKHIMANJU,ПАРАСКАР Абхиманью,SONI SHIVANI,СОНИ Шивани,SENGUPTA POULOMI,СЕНГУПТА Поуломи,BASU SUDIPTA,БАСУ Судипта
申请号:
RU2011134316/04
公开号:
RU0002538199C2
申请日:
2010.02.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to bio-compatible conjugated polymer nanoparticle, dicarbonyl-lipid compound, compound in form of vesicles, micelles or liposomes, containing multitude of nanoparticles, including said dicarbonyl-lipid compound, method of treating cancer or metastases, biocompatible polymer, as well as to conjugate. Biocompatible conjugated polymer nanoparticle includes main chain of copolymer, with at least one polymer monomer containing two side chains, selected from the group, consisting of carboxylic acid, amide and ester, and sad side chains are separated from each other by 1-1- carbon atoms, oxygen atoms or sulphur atoms, or their any combinations. Said nanoparticle further contains multitude of side chains, covalently bound with said main chain, with said side chains being selected from the group, consisting of monosaccharides, dicarboxylic acids, polyethyleneglycol and their combinations; and multitude of platinum compounds, dissociatedly bound with said main chain. Multiple platinum compounds are connected with said main chain via at least one coordination bond between carbonyl oxygen of carbonyl or amide group of main chain and platinum atom of platinum compound. Said platinum compound is selected from Pt(II) compounds, Pt(IV) compounds and any their combinations. Invention is also aimed at dicarbonyl-lipid compounds, in which platinum compound is dissociatedly bound with dicarbonyl compound. Invention is also aimed at method of treating cancer and metastases. Methods include selection of subject, requiring treatment of cancer or metastases, and introduction to subject of effective amount of nanoparticles, compounds or compositions of the invention.EFFECT: obtaining biocompatible conjugated polymer nanoparticles for chemotherapeutic platinum-based preparation.40 cl, 1 tbl, 29 dwg, 12 exИзобретение относится к биосовместимой конъюгированной полимерной наночастице, дикарбонил-липидному соединению, соединению в виде везикул, миц
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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