LEE, JIN K.,MILLER, BRIAN S.,WU, FANGJUN,BONI, LAWRENCE T.,MALININ, VLADIMIR
申请号：
CA2724230
公开号：
CA2724230C
申请日:
2009.02.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
One aspect of the disclosure relates to a new form of lipid-complexed activeplatinum compound, which allows forhigh concentrations of platinum compound in the composition. For example, theconcentration of cisplatin in the composition ishigher at room temperature, e.g., about greater than 1.2 mg/mL, compared to 1mg/mL in aqueous solution. In one embodiment,the present invention is directed to a composition comprising a lipid-complexed active platinum compound, wherein the complexhas a lipid to drug (L/D) ratio of less than about 1 by weight, e.g. about0.10 to 1, wherein the lipid-complexed active platinumcompound comprises at least one lipid and at least one active platinumcompound. In other embodiments, whereinlipid-com-plexed active platinum compound has an average volume-weighteddiameter of about 0.5 to about 20 microns. In still otherem-bodiments, the composition further comprises a liposome. The liposome maycomprise at least one lipid, and may furthercom-prise at least one active platinum compound. The disclosure also relatesto a pharmaceutical formulation comprising a lipidcom-plexed active platinum compound and a pharmaceutically acceptable carrieror diluent. The pharmaceutical formulation may beformulated for inhalation or injection.
