The novel pyrrazolopyridines according to Formula I, able to inhibit JAK is disclosed, these compound may be prepared as a pharmaceutical composition, and may be used for the prophylaxis and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.本發明揭示能夠抑制JAK之式I之新穎吡唑并吡啶，該等化合物可製成醫藥組合物形式，且可用於預防及治療哺乳動物(包含人類)之各種病狀，其作為非限制性實例包含過敏、發炎性病狀、自體免疫疾病、增殖性疾病、移植排斥、涉及軟骨代謝損傷之疾病、先天性軟骨畸形及/或與IL6分泌過多有關之疾病。
