A novel imidazolopyridine according to Formula I, able to inhibit JAK as disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.本發明揭示能夠抑制JAK之根據式I之新穎咪唑并吡啶，該化合物可製備成醫藥組合物形式，且可用於預防及治療包括人類在內之哺乳動物的多種病況，該等病況之非限制性實例包括過敏性或發炎病況、自體免疫疾病、增生性疾病、移植排斥反應、涉及軟骨代謝減弱之疾病、先天性軟骨畸形，及/或與IL6或干擾素分泌過多有關的疾病。
