作為雄激素受體調節劑之新穎咪唑啶化合物农业专利-农业学术服务平台

发明人:: 尼克　法兰希斯,尼克　法蘭希斯,JAGERSCHMIDT, CATHERINE,贾格史密特　凯萨琳,賈格史密特　凱薩琳,NAMOUR, FLORENCE SYLVIE,那尔　佛罗伦斯　希勒维,那爾　佛羅倫斯　希勒維,伯恩克　罗兰,伯恩克　羅蘭,拉富兰希欧　珍　麦尔,拉富蘭希歐　珍　麥爾,PEIXOTO, CHRISTOPHE,皮萨多　克里斯多夫,皮薩多　克里斯多夫,DEPREZ, PIERRE,迪,尼克法兰希斯,尼克法蘭希斯,贾格史密特凯萨琳,賈格史密特凱薩琳,那尔佛罗伦斯希勒维,那爾佛羅倫斯希勒維,伯恩克罗兰,伯恩克羅蘭,拉富兰希欧珍麦尔,拉富蘭希歐珍麥爾,皮萨多克里斯多夫,皮薩多克里斯多夫

摘要：: Novel compounds are disclosed that have a Formula represented by the following:wherein X, R1, R2a, R2b, R2c, R3aR3b, R4a, R4b, R4c, and ml are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction.本發明揭示下式代表之新穎化合物：其中X、R1、R2a、R2b、R2c、R3a、R3b、R4a、R4b、R4c及m1係如本文所述。該等化合物可製備為醫藥組合物，且可用於預防及治療包括人類之哺乳動物的各種病況，非限制性實例包括惡質病(cachexia)、骨質疏鬆症、肌肉減少症、性欲衰退及/或性功能障礙。