Rui Miguel Prudencio Pignatelli,Maria Manuel Dias Da Mota,Antonio Manuel Barbeiro Mendes
申请号：
US14394964
公开号：
US09655957B2
申请日:
2013.04.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method for inducing protective immunity in a vertebrate host against malaria, by administering to the host a live rodent Plasmodium organism and exploiting its cross-species protection potential.A method to use genetically engineered live rodent Plasmodium organisms expressing antigens from different stages of the life cycle of human-infective Plasmodium species to immunize vertebrate hosts against malaria.The invention further provides for the production of a vaccine composition, by suspending wild-type or genetically modified rodent Plasmodium organisms in a suitable pharmaceutically acceptable carrier solution.
