This invention, the autoimmune disease such as allergy disease and joint riumachi such as I type allergy disease and the inflammation characteristic intestinal disease effective, designates that the medicine and the food whose it is possible at the same time safely to remedy, to improve, or to prevent, or, are offered as purpose. Namely as for this invention, the rind and the seed of the grape fermenting each of them at least with the lactobacillus, in regard to the medicine which features that it includes grape rind seed lactobacillus fermentation ones which can, in addition, the rind and the seed of the grape fermenting each of them at least with the lactobacillus, it regards the food which features that it includes grape rind seed lactobacillus fermentation ones which can.本発明は、I型アレルギー疾患等のアレルギー疾患や、関節リウマチ、炎症性腸疾患等の自己免疫疾患を効果的、かつ安全に治療、改善、又は予防することが可能な医薬及び食品を提供することを目的とする。即ち本発明は、ブドウの果皮及び種子の少なくともいずれかを乳酸菌で発酵させて得られるブドウ果皮・種子乳酸菌発酵物を含むことを特徴とする医薬に関し、また、ブドウの果皮及び種子の少なくともいずれかを乳酸菌で発酵させて得られるブドウ果皮・種子乳酸菌発酵物を含むことを特徴とする食品に関する。
