MERCK SHARP & DOHME CORP.;Akhilesh BHAMBHANI;Rebecca LIZZANO;Jessica Sinacola;Robert K. EVANS
发明人:
Akhilesh Bhambhani,Robert K. Evans,Jessica Sinacola,Rebecca Lizzano
申请号：
US15029062
公开号：
US20160252300A1
申请日:
2014.10.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods for preparing dried pellets of biological materials are described. The pellets can have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a solid surface followed by microwave vacuum drying the frozen droplets. These methods are useful for preparing dried pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.
