SATHER, Blythe D.,BORGES, Christopher,BURLEIGH, Stephen Michael,NYE, Christopher Heath,VONG, Queenie,WELSTEAD, Gordon Grant
申请号：
AU2019247200
公开号：
AU2019247200A1
申请日:
2019.04.03
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Provided are methods for engineering immune cells, cell compositions containing engineered immune cells, kits and articles of manufacture for targeting nucleic acid sequence encoding a recombinant receptor to a particular genomic locus and/or for modulating expression of the gene at the genomic locus, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells. These may involve genetic disruption of at least one site within a TRAC gene and/or a TRBC gene and integration of the transgene encoding for the recombinant receptor at or near one of the at least one target site.
