The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering intraocular pressure and thereby treating glaucoma.本發明提供EP2激動劑、其製備方法、含有此等化合物之醫藥組合物及使用此等化合物及組合物降低眼內壓且藉此治療青光眼之方法。