The University Court of the University of Edinburgh
发明人:
Christopher Bruce Alexander Whitelaw,Christopher James Palgrave,Simon Geoffrey Lillico
申请号：
US16371824
公开号：
US20190216063A1
申请日:
2019.04.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a genetically edited animal, especially to a genetically edited pig in which expression or activity of the RELA protein has been modified. Such pigs have at least partial protection against the African Swine Fever Virus. The invention also provides, a cell nucleus, germ cell, stem cell, gamete, blastocyst, embryo, foetus and/or donor cell of a non-human animal comprising a genetic modification which alters the expression or function of RELA protein, methods for editing the genome of animals and methods for screening the efficacy of a pharmaceutical agent in such an animal.
