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Allosteric Enhancers of th A1 Adenosine Receptor
专利权人:
Pier Giovanni Baraldi
发明人:
Pier Giovanni Baraldi,Allan R. Moorman,Romeo Romagnoli
申请号:
US13347999
公开号:
US20120108636A1
申请日:
2012.01.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides compounds of formula (I)wherein W, R1, R5 and R6 have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric enhancers of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain, and inflammatory pain, cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke, neurological disease or injury, sleep disorders, epilepsy and depression.
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