A surgical access device comprises a cannula having a proximal end and a distal end. A housing is connected to the proximal end of the cannula and contains a zero-closure seal. The housing may also include a housing cap with a plurality of oblong apertures. A removable cap contains an instrument seal and comprises a plurality of distally extending L-shaped projections having a twist-to-lock engagement with the oblong apertures to attach the removable cap to the housing.
