Link Protein that binds to tumor necrosis factor alpha (TNF alpha)； Nucleic Acid Coding； vector； host Cell； production method； Pharmaceutical composition that comprises； its use to treat a disorder associated with TNF alpha； and a method for determining the presence of TNF -. In a sample.
Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.La solicitud describe proteínas de enlaces o porciones de enlace a antígenos de ellas que se unen específicamente a TNF-a, con el objetivo de inhibir la unión a su receptor. Se describe la humanización del anticuerpo monoclonal, MAK195, previamente descrito en la técnica.
