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Pyrrolidine derivatives
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- 申请号：
- ARP110104087
- 公开号：
- AR083700A1
- 申请日:
- 2011.11.03
- 申请国别(地区):
- AR
- 年份:
- 2013
- 代理人:
- 摘要：
- 1. Preparation process, preparation process and requirements 1: formula compound (1),wherein: R 1 is hydrogen, alkyl, morpholinyl, haloalkylamino, alkyloxyadiazolyl, hydroxy, halopyrrolidinyl, azetidinyl, alkylamino, amino, cyanoalkylamino, halophenyl alkylamino or cyanocycloalkylamino； R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkyloxy, halogen, hydroxyl, cyanopyrazinyloxy, pyrazolyl, alkylpyrazyl, imidazolyl, benzoimidazolyl, 6-oxo-6H-pyridazinyl, alkyl-6-oxo-6H-pyridazinyl, piperazinyl, N-alkylpiperazinyl, piperidinyl, difluoropyrrolidinyl, phenylimidazolyl, oxo-pyrrolidinyl, oxo-oxazolidinyl, morpholinyl, oxo-morpholinyl, oxo-pyridinyl, 2-pyrininyl, 2difluoropiperidinilo haloalquilpiperidinilo piperidinilalcoxi oxetaniloxi alquilpirazolilo halopiridinilo alquilpiridinilo cicloalquilo cicloalquilalquilo halofenilo alquilcarbonilaminocicloalquilalquilo haloalquilpiperazinilo alquilamino alcoxialquilpiperazinilo cicloalquilpiperazinilo hexahidropirrolo 1 2-a pirazinilo 5 6-dihidro-8H- 1 2 4 triazolo 4 3-a pirazin-7-ilo alquilimidazolilo azetidinilo cicloalquilpiperazinilo alquilimidazolilo alcoxialcoxi imidazo 4 5- Carbon-c (o) or-o is absent； A2 is nitrogen or CR7； A3 is nitrogen or CR8； A4 is nitrogen or CR9； R7 is hydrogen, tar, halide, halogen, hydroxyl, halocarbon； halobenzoic acid carbon, phenylcycloformamide, carbonate, haloacetylpropene propene propene acrylonitrile 1. Halogenated phenyl CYCLOPROPYLENE glycol or halogenated phenyl CYCLOPROPYLENE diallyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl allyl methyl ester； R9 is 1. Hydrogen, tar, halogen, halogen or nitrogen；R8 and R9, together with the carbon atoms to which they attach, form a cyclopentadiene or a pharmaceutically acceptable salt.Proceso de obtención, composiciones farmacéuticas y usos.Reivindicación 1: Un compuesto de la fórmula (1), en la que: R1 es hidrógeno,
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
