MIMÉTIQUES DE FORMULATIONS ORALES D'ACTIONS DE BYPASS GASTRIQUE ROUX-EN-Y SUR LE FREIN ILÉAL ； COMPOSITIONS, PROCÉDÉS DE TRAITEMENT, DIAGNOSTICS ET SYSTÈMES POUR LE TRAITEMENT DE MANIFESTATIONS DE SYNDROME MÉTABOLIQUE COMPRENANT L'INSULINO-RÉSISTANCE, LA STÉATOSE HÉPATIQUE, L'HYPERLIPIDÉMIE ET T2D
FAYAD; Joseph; M.;SCHENTAG, Jerome;FAYAD, Joseph, M.
发明人:
FAYAD, Joseph, M.,SCHENTAG, Jerome
申请号：
USUS2012/062306
公开号：
WO2013/063527A1
申请日:
2012.10.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides pharmaceutical compositions, methods for the treatment of, and related diagnostics and computer-implementable systems that relate to, the treatment of a variety of metabolic syndromes, including hyperlipidemia, weight gain, obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states. In an additional aspect of the invention, compositions and methods of treatment are calibrated to the ileal brake response to surgical intervention e.g. RYGB, as both activate the ileal brake, which acts in the gastrointestinal tract and the liver of a mammal to control metabolic syndrome manifestations and thereby reverse or ameliorate the cardiovascular damage (atherosclerosis, hypertension, lipid accumulation, and the like) resulting from progression of metabolic syndrome. The net benefit is the potential to treat all of the common manifestations of metabolic syndrome, including T2D and obesity, with one medicament, which contains glucose as an activation agent for the ileal brake. The ileal brake is the controller for progression of metabolic syndrome, and both RYGB surgery and the oral formulation act beneficially on the metabolic syndrome manifestations via this pathway. Disclosed as well are combination medicaments that act synergistically on the ileal brake and the manifestations of metabolic syndrome. In other aspects, the invention provides ileal brake hormone releasing compositions, methods of treatment, diagnostics, and related systems useful in selective control of appetite, stabilizing blood glucose and insulin levels, and treating gastrointestinal disorders in a similar manner to RYGB surgery, but having at least 20% of the potency to stimulate the hormonal response of the ileal brake of humans.L'invention concerne des compositions pharmaceutiques, des procédés pour le traitement - des diagnostics et des systèmes pouvant être mis en œuvre par ordinateur correspondants qui le concerne - d'u
