Recombinant bovine milk fat globule - EGF factor 8 (mfg-e8) protein, compared with EGF factor 8 (mfg-e8) protein, is a recombinant protein with anti tissue fibrosis function that can repair the tissue fibrosis level so that the level of tissue fibrosis is very close to the normal level Provision of the composition comprising.Recombinant protein for the prevention or treatment of tissue fibrosis characterized by a recombinant protein based on mfg-e8 protein and comprising a specific amino acid sequence.Diagram【課題】既存のウシ乳脂肪球-EGF因子8(MFG-E8)タンパク質に比べて、組織線維化の予防又は治療機能を改善して組織線維化のレベルが正常的なレベルに非常に近付くように修復可能なほどの抗組織線維化機能を備えた組換えタンパク質及びこれを含む組成物の提供。【解決手段】MFG-E8タンパク質を基に組換えされたタンパク質であって、特定のアミノ酸配列からなることを特徴とする、組織線維化の予防又は治療用の組換えタンパク質。【選択図】図1