The present invention resides in the discovery that the specific interaction between insulin-like growth factor 2 (IGF2) and integrin is involved in integrin-mediated cellular signaling, such as enhanced proliferation of cells expressing integrin, especially integrin αvβ3. Thus, this invention provides for a novel method for inhibiting integrin signaling by using an inhibitor of IGF1-integrin binding. A method for identifying inhibitors of IGF1-integrin binding is also described. Further disclosed are polypeptides, nucleic acids, and corresponding compositions for inhibiting integrin signaling.本發明在於發現似胰島素生長因子2(IGF2)與組合蛋白之間的特異性交互作用涉及組合蛋白媒介的細胞傳訊,諸如提高表現組合蛋白之細胞增生,該組合蛋白尤其是組合蛋白αvβ3。由此,本發明提供藉由使用IGF1組合蛋白結合抑制劑來抑制組合蛋白傳訊的新穎方法。亦描述用於識別IGF1組合蛋白結合抑制劑之方法。另揭露用於抑制組合蛋白傳訊的多肽、核酸及對應的組成物。
