ГХАЮР Тарик (US),МОРГАН-ЛЭПП Сьюзан Э. (US),РАЙЛИ Эдвард Б. (US),КИНГСБЕРИ Джиллиан А. (US),ФИЛЛИПС Эндрю (US),ВАН Цзеи (US),БЕЛЛ Рэнди Л. (US),НОРВЕЛЛ Сюзэнн М. (US),ЛИ Инчунь (US),ЛЮ Цзюньцзян (US)
申请号：
RU2010148418/10
公开号：
RU2010148418A
申请日:
2009.04.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A binding protein containing a polypeptide chain, where the specified polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 represents the first variable domain of the heavy chain obtained from the first parent antibody or its antigennegative part； ! VD2 is a second heavy chain variable domain derived from a second parent antibody or antigen binding portion thereof； ! C represents a constant domain of the heavy chain； ! (X1) n is a linker, provided that it is not CH1, wherein said (X1) n is either present or absent； and! (X2) n is an Fc region where said (X2) n is either present or absent； ! where a binding protein is capable of binding a pair of antigens selected from the group consisting of CD-20 and CD-19； CD-20 and CD-80； CD-20 and CD-22； CD-20 and CD-40； CD-3 and HER-2； CD-3 and CD-19； EGFR and HER-2； EGFR and CD-3； EGFR and IGF1,2； EGFR and IGF1R； EGFR and RON； EGFR and HGF； EGFR and c-MET； HER-2 and IGF1,2； HER-2 and IGF1R； RON and HGF； VEGF and EGFR； VEGF and HER-2； VEGF and CD-20； VEGF and IGF1,2； VEGF and DLL4； VEGF and HGF； VEGF and RON； VEGF and NRP1； CD-20 and CD3； DLL-4 and PLGF； VEGF and PLGF, ErbB3 and EGFR, HER-2 and ErbB3, ErbB3 and HGF； HER-2 and PLGF, and HER-2 and HER-2. ! 2. The binding protein according to claim 1, where VD1 and VD2 contain an amino acid sequence selected from the group consisting of SEQ ID NO: 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49 , 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91 and 93.! 3. A binding protein containing a polypeptide chain, where the specified polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 is a light chain variable domain derived from a first parent antibody or antigen binding portion thereof； ! VD2 is a light chain variable domain derived from a second parent antibody or antigen binding portion thereof； ! C is a constant domain easy1. Связывающий белок, содержащий полипептидную цепь, где указанная полипептидная цепь содержит VD1-(X1)
