HIRST Gavin (US),ХЕРСТ Гэвин (US),REDDY Raja (US),РЕДДИ Раджа (US),HECKER Scott (US),ХЕККЕР Скотт (US),TOTROV Maxim (US),ТОТРОВ Максим (US),GRIFFITH David C. (US),ГРИФФИТ Давид С. (US),RODNV Olga (US),HIRST Gavin,ХЕРСТ Гэвин,REDDY Raja,РЕДДИ Раджа,HECKER Scott,ХЕККЕР Скотт,TOTROV Maxim,ТОТРОВ Максим,GRIFFITH David C.,ГРИФФИТ Давид С.,RODNV Olga,РОДНИ Ольга,DUDLEV Michael N.,ДАДЛИ Михаил Н.,BOVER Se
申请号：
RU2013104951/04
公开号：
RU0002599791C2
申请日:
2011.08.08
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Values of radicals are as follows: Y is a 1-4 atom alkylene or 2-4 atoms alkenylene linker； R1 is selected from a group consisting of -C1-9-alkyl,-C2-9-alkenyl, -C2-9-alkynyl, -NR9R10, -C1-9-alkyl-R11, -C2-9-alkenyl-R11, -C2-9-alkynyl-R11, -carboxylic radical-R11, -CH(OH)C1-9-alkyl-R9, -CH(OH)C2-9-alkenyl-R9, -CH(OH)C2-9-alkynyl-R9, -CH(OH)-carboxylic radical-R9, -C(=O)R9, -C(=O)C1-9-alkyl-R9, -C(=O)C2-9-alkenyl-R9, -C(=O)C2-9-alkynyl-R9, -C(=O)C2-9-carboxylic radical-R9, -C(=O)NR9R10, -N(R9)C(=O)R9, -N(R9)C(=O)NR9R10, -N(R9)C(=O)OR9, -N(R9)C(=O)C(=NR10)R9, -N(R9)C(=O)C(=CR9R10)R9, -N(R9)C(=O)C1-4-alkyl-N(R9)C(=O)R9, -N(R9)C(=NR10)R9, -C(=NR10)NR9R10, -N=C(R9)NR9R10, -N(R9)SO2R9, -N(R9)SO2NR9R10, -N=CHR9, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carboxylic radical and substituted or unsubstituted heterocyclic radical； R6 is hydrogen； R7 is hydrogen； R8 is hydrogen； each R9 is independently selected from a group consisting of H, -C1-9-alkyl, C2-9-alkenyl, -C2-9-alkynyl, carboxylic radical, -C1-9-alkyl-R11, -C2-9-alkenyl-R11, -C2-9-alkynyl-R11, -carboxylic radical-R11, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carboxylic radical and substituted or unsubstituted heterocyclic radical； each R10 is independently selected from a group consisting of H, -C1-9-alkyl, -OR9, -CH (=NH), -C (=O)OR9, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carboxylic radical and substituted or unsubstituted heterocyclic radical； each R11 is independently selected from a group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carboxylic radical and substituted or unsubstituted heterocyclic radical； X is -CO2R12； R12 is sel
