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METHODES DE EX-VIVO DE SOINS D'ORGANES PAR L'UTILISATION DE LACTATE COMME INDICATEUR
专利权人:
Transmedics; Inc.
发明人:
申请号:
EP08795820.3
公开号:
EP2150105B1
申请日:
2008.04.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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